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High Impact around the World
Explore the Brain and Brain Communications articles that have been the most popular around the world in the last year. This collection provides access to a selection of the most read papers globally and by continent.
Browse the collectionDec 05, 2019 Deceptively challenging physics puzzles for your brain! Draw shapes to solve challenging physics puzzles. They're not as easy as they look. Care to give one a try? Dozens of brain busting physics puzzles, with more being added all the time Compete with your friends for the Brain It On! Crown Multiple ways to solve each puzzle, can you find the best solution? Share your unique solutions. (a) Bioanalyzer traces of DroNc-seq libraries showing the length of the cDNA library fragments of (from left): 3T3 cells, 3T3 nuclei, human brain nuclei, and mouse brain nuclei.
Editor's Choice
Editor's Choice Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson’s disease
Chu et al. present findings from post-mortem assessment of two individuals with advanced Parkinson’s disease who received gene therapy with the trophic factor neurturin, 8 and 10 years prior to death. The cases represent the longest survival times reported to date for recipients of gene therapy for Parkinson’s disease.
Editor's Choice Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum
Bevan-Jones, Cope et al. report that neuroinflammation co-localizes with protein aggregation in all major types of frontotemporal dementia, both in vivo with positron emission tomography, and at post mortem. In vivo neuroinflammation patterns are disease-specific and can accurately classify patients into groups.
Editor's Choice Dynamics of recovery from anaesthesia-induced unconsciousness across primate neocortex
How does the brain recover from general anaesthesia? By studying intracortical neuronal dynamics during the transition in primates, Patel et al. show that the return of consciousness corresponds with an abrupt shift of neuronal dynamics across neocortex and is not simply the inverse of the loss of consciousness.
Editor's Choice Clinical, morphological and genetic characterization of Brody disease: an international study of 40 patients
Brody disease is a rare myopathy characterized by exercise-induced muscle stiffness caused by mutations in the ATP2A1 gene. In the largest cohort of Brody patients to date, Molenaar et al. clarify the phenotype and diagnostic possibilities to help improve understanding and recognition of this distinct myopathy.
Editor's Choice Resective epilepsy surgery in tuberous sclerosis complex: a nationwide multicentre retrospective study from China
At least 50% of patients with tuberous sclerosis complex present with intractable epilepsy. Liu et al. report the long-term seizure and neuropsychological outcomes of resective surgery in more than 350 patients, including rates of seizure control after 1, 4 and 10 years.
Editor's Choice Topography of the pain in classical trigeminal neuralgia: insights into somatotopic organization
Neurovascular conflict gives rise to classical trigeminal neuralgia, but factors determining the topographical distribution of the pain are unclear. Sindou et al. show an association between the location of the conflict around the trigeminal root and pain distribution, suggesting a somatotopic organization of the root.
Latest articles
Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease
Protective effects of 4-aminopyridine in experimental optic neuritis and multiple sclerosis
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Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
Bi-allelic GAD1 variants cause a neonatal onset syndromic developmental and epileptic encephalopathy
Most read
Clinical presentation and prognosis in MOG-antibody disease: a UK study
Encephalitis lethargica: 100 years after the epidemic
Symptoms and signs of syncope: a review of the link between physiology and clinical clues
The mismatch negativity: an index of cognitive decline in neuropsychiatric and neurological diseases and in ageing
Hubris syndrome: An acquired personality disorder? A study of US Presidents and UK Prime Ministers over the last 100 years
Alzheimer's Collection
Explore Brain's collection of highly cited Alzheimer's papers, and some of the first research published in Brain Communications. All articles are Open Access or have been made freely available online.
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Introducing Brain Communications
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Brain Communications is the open access sister journal to Brain, publishing high-quality preclinical and clinical studies related to diseases of the nervous system or maintaining brain health.
How air pollution may lead to Alzheimer’s disease
Air pollution harms billions of people worldwide. Over the past few decades, it has become widely recognized that outdoor air pollution is detrimental to respiratory and cardiovascular health, but recently scientists have come to acknowledge the damage it may cause on the brain as well.
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When narcolepsy makes you more creative
Patients with narcolepsy are often lucid dreamers, and experience direct transitions from wakefulness into REM sleep. Lacaux et al. report that these patients perform better than healthy controls on creativity tests, supporting a role for REM sleep in creativity.
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Better detection of concussions using vital signs
We have vital signs for our body like heart rate, body temperature, respiratory rate, and blood pressure. Why not for our brain? You can’t treat what you can’t measure, bottom line. Therefore, we must first know if brain injuries, like concussions, have significantly affected brain function.
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Top trending articles
Discover the top Brain articles sorted by Altmetric Score, that have been mentioned online in the past three months.
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